Cheap flights from San Francisco to Santiago (SFO to SCL) from $637

Book at the right time: For international flights, aim to book 6–10 weeks ahead. Last-minute fares on San Francisco to Santiago are rarely cheap, and prices spike sharply within 2 weeks of departure.

Shift your dates by a day or two: Mid-week departures (Tuesday–Wednesday) are almost always cheaper than weekend flights. Even shifting by one day can make a meaningful difference.

Weigh up connecting flights: Connecting flights on San Francisco to Santiago can be 20–40% cheaper than direct options. If you have time to spare, it's worth comparing.

Factor in baggage fees: Low-cost carriers on this route often advertise attractive base fares but charge separately for checked luggage. Always compare the all-in price — a $20 cheaper fare plus $50 baggage fee is no saving. Aeromexico and Air Canada may have different inclusions, so check each airline's fare conditions.

Search in private browsing: Some booking sites use cookies to track repeat searches and may show higher prices after multiple lookups. Use an incognito or private window — or just use Booked AI, which pulls live prices without any tracking markup.

Compare two one-ways against a return: On some international routes, booking a one-way with one airline and the return with another can undercut a standard return ticket — especially if a budget carrier covers one direction. Check both options with the flexible dates calendar above.

The cheapest flights from San Francisco to Santiago start from $637, with typical prices ranging from $637 to $896.

The typical flight time from San Francisco to Santiago is approximately 18 hours and 32 minutes.

Airlines operating this route include Aeromexico, Air Canada, Alaska Airlines, American Airlines, Avianca, Copa Airlines, Iberia, LATAM Airlines, Turkish Airlines.